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The EVRENZO “ALPINE” clinical efficacy programme1

A comprehensive range of EVRENZO clinical trials involving 9,600 patients1

Included patients with non-dialysis-dependent, incident dialysis-dependent, and stable dialysis-dependent CKD.1

Evidence_graph
  • Ast=Astellas trial
  • AZ=AstraZeneca trial
  • Fib=Fibrogen trial
  • *Darbepoetin-alfa active comparator
  • **Subset of patients with >2 weeks and <4 months of dialysis at the time of randomisation
    †Epoetin-alfa active comparator
  • ††Subset of patients with >4 months of dialysis at the time of randomisation
  • ‡Darbepoetin-alfa or epoetin-alfa active comparator

CKD, chronic kidney disease; DD, dialysis-dependent; ESA, erythropoiesis-stimulating agent; Hb, haemoglobin; IV, intravenous; NDD, non-dialysis-dependent.

Reference

  • EVRENZO SmPC.
  • Barratt J et al. Nephrol Dial Transplant. 2021;36(9):1616–1628.
  • Shutov E et al. Nephrol Dial Transplant. 2021;36(9):1629–1639.
  • Coyne DW et al. Kidney Int Rep. 2020;6:624–635.
  • Fishbane S et al. J Am Soc Nephrol. 2021;32:737–755.
  • Provenzano R et al. Nephrol Dial Transplant. 2021;36(9):1717–1730.
  • Fishbane S et al. J Am Soc Nephrol. 2022;33:850–866.
  • Charytan C et al. Kidney Int Rep. 2021;6(7):1829–1839.
  • Csiky B et al. Adv Ther. 2021;38(10):5361–5380.

Reference

  • EVRENZO SmPC.